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What is the mechanism of action of indoxacarb, and which pests does it control?
Apr 09,2026
Indoxacarb is a broad-spectrum diazinon insecticide, a sodium ion channel blocking insecticide. Indoxacarb has contact and stomach poison effects and can effectively control a variety of pests on crops such as grains, cotton, fruits, and vegetables. It is mainly used to control cabbage caterpillars, diamondback moths, beet armyworms, and cotton bollworms.
Mechanism of Action of Indoxacarb:
Indoxacarb is a sodium ion channel inhibitor with two isomers, S and R. The S isomer is the active active form, hence the common usage of "S-isomer indoxacarb." When the pesticide enters the insect's body, it rapidly transforms into a special metabolite. This substance irreversibly blocks sodium ion channels within the insect's nerve cells, preventing nerve impulse transmission and causing nerve cell dysfunction. This leads to paralysis, loss of feeding ability, and ultimately, stiffening and death. Insects exposed to indoxacarb cease feeding and become immobile within 4 hours, with no reversible or recoverable effects, dying within 2-3 days. Therefore, this insecticide typically does not exhibit cross-resistance with other insecticides such as organophosphates and pyrethroids. It is active against pests of all instars, has high safety for non-target organisms, and leaves minimal residues in crops.
Insecticidal Spectrum of Indoxacarb:
Suitable for controlling beet armyworm, diamondback moth, cabbage worm, cotton bollworm, tobacco budworm, leafroller, codling moth, leafhopper, inchworm, diamondback moth, and potato beetle on crops such as cabbage, cauliflower, kale, tomato, pepper, cucumber, cucumber, eggplant, lettuce, apple, pear, peach, apricot, cotton, potato, grape, and tea.
Indoxacarb can also be used to control most lepidopteran pests on grain crops such as corn and rice, including rice stem borers, rice borers, leafrollers, and fruit borers, as well as leafhoppers, beetles, and red imported fire ants. It can also control sanitary pests such as mosquitoes and ants.
It has stomach poison and contact action, but no systemic activity. However, it has good penetrability; after contact with plant leaves, the pesticide will be absorbed onto the leaf surface and penetrate into the leaf tissue. It is resistant to rain washout, but should be used with caution in high-temperature environments. It does not exhibit cross-resistance with most insecticides.
Indoxacarb is a low-toxicity insecticide, slightly toxic to mammals and birds, safe for natural enemies and crops, highly toxic to fish and bees, and extremely toxic to silkworms.
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